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Non sedating allergy

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Often referred to as the nonsedating antihistamines.

They compete with histamine for histamine receptor type 1 (H1) receptor sites in the blood vessels, GI tract, and respiratory tract, which, in turn, inhibits physiologic effects that histamine normally induces at the H1 receptor sites.

Some do not appear to produce clinically significant sedation at usual doses, while others have a low rate of sedation.

All are efficacious in controlling symptoms of allergic rhinitis (ie, sneezing, rhinorrhea, itching) but do not significantly improve nasal congestion.

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Current guidelines for diagnosis and treatment of allergic rhinoconjunctivitis and urticaria recommend nonsedating antihistamines as first line treatment [1, 2].Since the arrival of the second-generation, non-sedating antihistamines a decade or more ago, the first-generation drugs have fallen out of favor.Why take something that causes such bothersome side effects when you can take something just as effective that doesn’t?The observations indicate that non-sedating antihistamines, as opposed to what has been thought previously, may be helpful in patients with allergic rhinitis in whom nasal obstruction is a major concern.Current international guidelines need to be revised in the light of the recent evidence.Clinical studies sponsored by the manufacturer have shown that bilastine 20 mg once daily is as efficacious as other nonsedating antihistamines in allergic rhinoconjunctivitis and chronic urticaria in individuals from 12 and 18 years of age, respectively.